entertainment for events: March 2012

Saturday, March 31, 2012

Fighting rages near key Sudan border village

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A Fistful of Smart Media Dollars

The rise of smart, multi-screen streaming media is fundamentally changing the TV experience. This year, for the first time ever, Americans will watch more movies over the Internet than on physical media like DVD and Blu-ray. Ooyala?s Video Index Report found that non-desktop video plays doubled in the fourth quarter of 2011. Tablet sales continue to explode. People now spend more time on Xbox Live streaming movies and TV shows than playing video games. And consumer electronics manufacturers are gearing up to ship 125 million Smart TVs in 2014. Simply put, TV is no longer constrained to a single box, a single screen, or a single UI. Smart networks, broadcasters, studios and service providers recognize that there?s real money to be made as TV moves into the information age. People are not only watching more movies and TV shows online, they are paying for access to premium video content. Recent studies reveal that over half of American tablet owners paid to watch a movie in Q4 2011 and more than 40% paid for TV content. These are strong signs that we?ve come a long way from Jeff Zucker?s ?digital pennies? remark back in 2008.

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Note to Mega Millions lottery winner: Beware! (+video)

Sure, the jackpot for the Mega Millions lottery is an all-time high of $640 million ? and ticket sales on Friday are through the roof. But winning brings its own complications. Read on.

By Ron Scherer,?Staff writer, Kara Bloomgarden-Smoke,?Contributor / March 30, 2012

Here's a cautionary tale for anyone dreaming of winning the record $640 million Mega Millions jackpot Friday night: It?s a dangerous world out there for lottery winners.

Skip to next paragraph The jackpot in the Mega-Millions lottery drawing Friday is set to an all-time record triggering lottery mania across the United States.

The winner, warns Chicago lawyer Andrew Stoltmann, will be besieged by con artists, investment scams, family members whom they haven?t seen in decades, and scores of charities ? some legitimate, some imaginary.?

?It is tragic,? says Mr. Stoltmann, who represents a man whose $5.5 million lottery winnings were wiped out due to what the lawyer says was bad investment advice.

Others say what's tragic is that more people don?t pay heed to the miniscule chance of winning the Mega Millions. According to lottery officials, the odds of possessing the winning ticket are 1 in 176 million ? meaning an individual would be more likely to get hit by lightning or be eaten by a shark. One statistician notes that the Chicago Cubs have a better chance of winning the World Series this year.

?People know there are long odds,? says Scott Hoover, a professor of business administration at Washington and Lee University in Lexington, Va. ?But people are irrational in buying. They see it as a form of entertainment because if you look at it as an investment, it?s a horrible thing to do.?

Some buyers are well aware that winning is a very remote possibility. At New York?s Port Authority bus terminal, Henry Wallace is among the lottery players lined up Friday at a Hudson News kiosk.?

?I figure it?s about the same as the chances of Nicole Kidman walking into the Port Authority and handing me an Oscar,? says Mr. Wallace, who works for the Bergen County (New Jersey) government. ?But why not? It?s just a dollar and a dream.?

But this week, for every American who sees buying a ticket as a waste of good money, there's another who is eager to be parted from his or her earnings. The pace at which Mega Millions tickets have been selling is phenomenal. Since Tuesday, Mr. Hoover estimates, people have spent about $600 million on tickets ? and perhaps as much as $1.2 billion since the last winner on Jan. 24. In Massachusetts, tickets were selling at the rate of 14,000 per minute on Friday, says Beth Bresnahan, a spokeswoman for the Massachusetts Lottery.

?This is unprecedented,? says Ms. Bresnahan. ?The scale of this thing is driving the increase. People are coming out of the woodwork.?

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Consumer Loans BLOG? Blog Archive ? Recent Grads Looking to ...

New York, NY (PRWEB) March 27, 2012

Supplyloans.com takes a careful examination on the beneficial and the disadvantageous connections between student loan and consolidation. The comprehensive financial site currently features informative pieces to eliminate any confusion and uncertainty over debt consolidation.

College debt haunts many working professionals today. The anxiety over hundreds of thousands of debt can exponentially increase with low-income workers who have to deal with financial volatility, especially in a precarious economy. It takes years, even decades, for most professionals to finally and completely pay off student loans.

With clear and concise language, Supplyloans.com currently offers a profoundly easy brief on consolidating college debt. ?It combines all the college loans into one and there?s only one single payment to be made. Federal loans can be combined into one while private loans can be combined to the federal loans. The length of time for the college loan consolidation will depend on the total amount due after all loans are consolidated.?

Site visitors hoping to consolidate school loan are presented with realistic scenarios to aid them in making informed choices that pave the way for debt relief. Supplyloans.com clarifies, ?One advantage you get if you consolidate your loans is you no longer have to remember different due dates and monthly payments. If you consolidate, you get to have one exact date and one due amount to keep in mind. On the other hand? it?s consolidated so you are to expect a larger loan repayment amount.?

The financial website furthers weighs in on student debt consolidation, adding, ?It reduces the amount of your monthly installment and it increases the time period of the loan.?

Alongside informative pieces on loan consolidation, Supplyloans.com also features enlightening articles on personal finance, investment, wealth building and other finance related matters.

Supplyloans.com reinforces the idea that there are two sides to a coin with articles that neither advocate nor oppose one option over the other. While the site is in no way a substitute for getting professional financial advice, it still figures as a substantial resource for recent grads and borrowers seeking financial options and eventual relief from college loans.

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Newly identified stem cells may hold clues to colon cancer

Thursday, March 29, 2012

Vanderbilt-Ingram Cancer Center researchers have identified a new population of intestinal stem cells that may hold clues to the origin of colorectal cancer.

This new stem cell population, reported March 30 in the journal Cell, appears to be relatively quiescent (inactive) ? in contrast to the recent discovery of intestinal stem cells that multiply rapidly ? and is marked by a protein, Lrig1, that may act as a "brake" on cell growth and proliferation.

The researchers have also developed a new and clinically relevant mouse model of colorectal cancer that investigators can now use to better understand where and how the disease arises, as well as for probing new therapeutic targets.

Colorectal cancer is the second leading cause of cancer deaths in the United States. These tumors are thought to arise from a series of mutations in intestinal stem cells, which are long-lived, self-renewing cells that gives rise to all cell types in the intestinal tract.

For more than 30 years, scientists believed that intestinal stem cells were primarily quiescent, proliferating only rarely in order to protect the tissue against cancer. Then, in 2007, researchers reported finding a population of intestinal stem cells (marked by the molecule Lgr5) that were highly proliferative.

Those findings "really changed the way we think about intestinal stem cells," said Robert Coffey, Jr., M.D., Ingram Professor of Cancer Research, co-chair of Vanderbilt's Epithelial Biology Center and senior author on the study.

"It came to so dominate the field that it raised the question about whether quiescent stem cells even exist?and that's where we enter into the picture."

Coffey's lab studies the epidermal growth factor (EGF) signaling pathway ? which includes a family of receptors known as ErbBs ? and its role in cancers of epithelial tissues, like the intestinal tract.

Postdoctoral fellow Anne Powell, Ph.D., led the recent experiments showing that Lrig1, a molecule that regulates ErbB activity, is present in intestinal cells that have the qualities of stem cells (self-renewal, and the ability to produce all the cells of the intestine).

"Essentially, what we show is that the Lrig1-expressing cells are stem cells and they are largely quiescent," Powell said. "We also show that they're distinct from the Lgr5-expressing stem cells that had become a sort of 'hallmark' stem cell population?with different gene expression profiles and different proliferative status."

They also showed that Lrig1 is not only a marker of intestinal stem cells, but also acts as a tumor suppressor and inhibits the growth and proliferative signals of the ErbB family ? acting as a sort of "brake" on cell proliferation that can lead to cancer.

Postdoctoral fellow Yang Wang, Ph.D., eliminated Lrig1 in mice and showed that nearly all of those mice developed intestinal tumors, providing further evidence suggesting that Lrig1 functions as a tumor suppressor.

The findings underscore the importance of ErbB signaling in the behavior of intestinal stem cells from which colorectal cancer may arise.

Most exciting, said Coffey, is that the mouse model his lab has generated as a part of these studies is one of the only mouse models to develop tumors in section of the intestines where most human tumors develop: the colon. One additional advantage of this model, in contrast to others, is that the tumors develop quickly and can be easily monitored with endoscopy, which will make it easier to assess how therapeutic interventions are working.

"We are fairly confident that this will be the 'go-to' model to study colon cancer in mice for the foreseeable future," Coffey said.

###

Vanderbilt University Medical Center: http://www.mc.vanderbilt.edu/npa

Thanks to Vanderbilt University Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Brain wiring a no-brainer?

ScienceDaily (Mar. 29, 2012) ? The brain appears to be wired more like the checkerboard streets of New York City than the curvy lanes of Columbia, Md., suggests a new brain imaging study. The most detailed images, to date, reveal a pervasive 3D grid structure with no diagonals, say scientists funded by the National Institutes of Health.

"Far from being just a tangle of wires, the brain's connections turn out to be more like ribbon cables -- folding 2D sheets of parallel neuronal fibers that cross paths at right angles, like the warp and weft of a fabric," explained Van Wedeen, M.D., of Massachusetts General Hospital (MGH), A.A. Martinos Center for Biomedical Imaging and the Harvard Medical School. "This grid structure is continuous and consistent at all scales and across humans and other primate species."

Wedeen and colleagues report new evidence of the brain's elegant simplicity March 30, 2012 in the journal Science. The study was funded, in part, by the NIH's National Institute of Mental Health (NIMH), the Human Connectome Project of the NIH Blueprint for Neuroscience Research, and other NIH components.

"Getting a high resolution wiring diagram of our brains is a landmark in human neuroanatomy," said NIMH Director Thomas R. Insel, M.D. "This new technology may reveal individual differences in brain connections that could aid diagnosis and treatment of brain disorders."

Knowledge gained from the study helped shape design specifications for the most powerful brain scanner of its kind, which was installed at MGH's Martinos Center last fall. The new Connectom diffusion magnetic resonance imaging (MRI) scanner can visualize the networks of crisscrossing fibers -- by which different parts of the brain communicate with each other -- in 10-fold higher detail than conventional scanners, said Wedeen.

"This one-of-a-kind instrument is bringing into sharper focus an astonishingly simple architecture that makes sense in light of how the brain grows," he explained. "The wiring of the mature brain appears to mirror three primal pathways established in embryonic development."

As the brain gets wired up in early development, its connections form along perpendicular pathways, running horizontally, vertically and transversely. This grid structure appears to guide connectivity like lane markers on a highway, which would limit options for growing nerve fibers to change direction during development. If they can turn in just four directions: left, right, up or down, this may enforce a more efficient, orderly way for the fibers to find their proper connections -- and for the structure to adapt through evolution, suggest the researchers.

Obtaining detailed images of these pathways in human brain has long eluded researchers, in part, because the human cortex, or outer mantle, develops many folds, nooks and crannies that obscure the structure of its connections. Although studies using chemical tracers in neural tracts of animal brains yielded hints of a grid structure, such invasive techniques could not be used in humans.

Wedeen's team is part of a Human Connectome Project Harvard/MGH-UCLA consortium that is optimizing MRI technology to more accurately to image the pathways. In diffusion imaging, the scanner detects movement of water inside the fibers to reveal their locations. A high resolution technique called diffusion spectrum imaging (DSI) makes it possible to see the different orientations of multiple fibers that cross at a single location -- the key to seeing the grid structure.

In the current study, researchers performed DSI scans on postmortem brains of four types of monkeys -- rhesus, owl, marmoset and galago -- and in living humans. They saw the same 2D sheet structure containing parallel fibers crossing paths everywhere in all of the brains -- even in local path neighborhoods. The grid structure of cortex pathways was continuous with those of lower brain structures, including memory and emotion centers. The more complex human and rhesus brains showed more differentiation between pathways than simpler species.

Among immediate implications, the findings suggest a simplifying framework for understanding the brain's structure, pathways and connectivity.

The technology used in the current study was able to see only about 25 percent of the grid structure in human brain. It was only apparent in large central circuitry, not in outlying areas where the folding obscures it. But lessons learned were incorporated into the design of the newly installed Connectom scanner, which can see 75 percent of it, according to Wedeen.

Much as a telescope with a larger mirror or lens provides a clearer image, the new scanner markedly boosts resolving power by magnifying magnetic fields with magnetically stronger copper coils, called gradients. Gradients make it possible to vary the magnetic field and get a precise fix on locations in the brain. The Connectom scanner's gradients are seven times stronger than those of conventional scanners. Scans that would have previously taken hours -- and, thus would have been impractical with living human subjects -- can now be performed in minutes.

"Before, we had just driving directions. Now, we have a map showing how all the highways and byways are interconnected," said Wedeen. "Brain wiring is not like the wiring in your basement, where it just needs to connect the right endpoints. Rather, the grid is the language of the brain and wiring and re-wiring work by modifying it."

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The above story is reprinted from materials provided by NIH/National Institute of Mental Health.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Van J. Wedeen, Douglas L. Rosene, Ruopeng Wang, Guangping Dai, Farzad Mortazavi, Patric Hagmann, Jon H. Kaas, and Wen-Yih I. Tseng. The Geometric Structure of the Brain Fiber Pathways. Science, 30 March 2012: 1628-1634 DOI: 10.1126/science.1215280

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Sex and Relationships with Mikaya Heart ? DangerousLee.Biz

Failing to deal well with emotions is probably the single biggest cause of problems in relationships, especially as sex tends to bring up feelings. Yet they are rarely understood in this society. Here is quick primer:

1. Feelings are not facts but they often affect us much more than facts.

2. Feelings may carry tremendous energy which makes them very powerful.

3. Trying to rationalize someone out of a feeling (?There?s no reason to be so angry about it!?) is not likely to make someone feel better, although it may enable him or her to see that the original basis for the feeling goes beyond the present situation.

4. Feelings always want to be felt and they will usually pass quite quickly if you allow yourself to express them fully.

5. Feelings that we do not allow ourselves to feel in the moment when they arise hang around, sometimes for many years, waiting for an opportunity to be expressed. Old stuck feelings sap our energy and effectively prevent us from being clear channels of energy.

6. If you do clear out old feelings, you will find that new feelings that come up are always related to the present situation and they are hugely informative. Every feeling has something to tell you.

You can see that it is a very good idea to pay attention to feelings. If they are triggered in a way that seems out of proportion to the present moment, then you have been storing them from the past. Addressing the past and letting them move on is well worth the effort. Repressing feelings is a major source of stress and tension in modern society.

It is often better not to take action when you are in the middle of experiencing an intense feeling. Strong feelings around a particular person may indicate some action is necessary in order for you to take care of yourself or of someone else, but we are not always able to see clearly when we are seeing red. Allow the intensity of the feeling to recede, then consider appropriate action when you are more able to be rational.

More about how to deal with feelings next time . . .

Mikaya Heart is an award-winning author and life-coach. Her latest book is The Ultimate Guide to Orgasm for Women. www.mikayaheart.org

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Source: http://dangerouslee.biz/2012/03/30/sex-and-relationships-with-mikaya-heart-7/

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Insight: New doubts about prostate-cancer vaccine Provenge | Odd ...

By Sharon Begley

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NEW YORK | Fri Mar 30, 2012 1:08am EDT

NEW YORK (Reuters) ? Prostate cancer vaccine Provenge has long incited passions unlike any other cancer therapy.

Doctors who raised doubts about it received death threats. Health regulators and lawmakers faced loud protests at their offices. A physician at the American Cancer Society was so intimidated by Provenge partisans that he yanked a skeptical discussion of it from his blog.

The vitriol dissipated in April 2010, when the U.S. Food and Drug Administration approved Provenge for advanced prostate cancer, satisfying investors in manufacturer Dendreon and patients who for years had demanded it be put on the market.

But the bell on Round Two sounded when Marie Huber, a trained scientist and former hedge-fund analyst, made it her mission in the last year to analyze what she believes are deadly flaws in the studies that led to the approval of Provenge by the FDA.

She argues that the main reason Provenge seemed to extend survival ? a crucial factor in the FDA?s decision ? was that older men in the study who did not receive Provenge died months sooner than similar patients?

This article can be read in its entirety by subscription members. (With no advertisements!)

(Use promo code ?Leapfrog? and the first month is free!)
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Source: http://www.oddonion.com/2012/03/30/insight-new-doubts-about-prostate-cancer-vaccine-provenge/

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Iraq vet uses rear naked choke to stop robbery

You walk into a store and see someone holding up the cashier. What do you do? If you're Zack Thome, an Iraq vet and someone who has trained in MMA, you slap a rear naked choke on the offender and choke him out.

Original Video- More videos at TinyPic

Thome held Brandon Slanger, the suspect who is said to be schizophrenic, down as someone else called the police. Thome said he lives near the store and didn't want to see the cashier hurt.

"It's kind of my hometown.? I live right next to the place, you know, I'm in there everyday.? I think if it was the other way around, if I worked there and the guy at the register was there, he would have done the same thing," said Thome.

Kudos to Thome for using his MMA training to good use. But unless you've actually trained, don't try this at home, folks. Watching every UFC pay-per-view doesn't count.

Gracias, Cage Potato.

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Source: http://sports.yahoo.com/blogs/mma-cagewriter/iraq-vet-uses-rear-naked-choke-stop-robbery-130652301.html

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Consulting News: PwC Named a Leader in Global Business ...

PwC has announced it has been named a leader in business consulting services in the worldwide, Americas, and EMEA (Europe, Middle East and Africa) markets, according to the 2012 IDC MarketScape reports. The IDC MarketScape reports are based on a vendor analysis model designed to provide an overview of the competitive fitness of suppliers in a given market.

According to the reports, PwC is recognized as achieving the "Leader" classification in three regions including the worldwide, Americas and EMEA markets. PwC is also considered a "Major Player" in the Asia/Pacific market. According to IDC:

"Worldwide, PwC is seen as better than many of its peers at providing a full spectrum of business consulting services and at helping enterprises comply with new or existing regulations and manage risk. PwC is also seen as better than many of its peers at helping clients reduce costs."

"[In the Americas,] PwC is seen as among the most capable at integrating its project team with the client's and at providing a full spectrum of business consulting services. It is also seen as better than many of its peers at challenging corporate culture."

"In the Americas, PwC is seen as better than many of its peers at delivering innovation in the project and at delivering ROI for the project. It is also seen as better than many of its peers at helping clients expand into new markets or geographies and at helping clients identify and implement options for growth."

"[In EMEA,] PwC is seen as better than many of its peers at providing a full spectrum of business consulting services."

"In Asia/Pacific, PwC is seen as better than many of its peers at applying proven methodologies/tools and leveraging local resources."

"PwC's consistent ranking in IDC's series of MarketScape reports underscores our focus on delivering high quality and relevant advisory services to clients around the world, helping them from strategy through execution to achieve a competitive advantage in today's market," said Dana Mcilwain, PwC Vice Chairman and U.S. Advisory Leader. "Our "Leader" and "Major Player" rankings reflect our commitment to building deep relationships with our clients, working closely with them to find opportunities for innovation and growth, manage risk and address their most pressing business challenges."

About IDC MarketScape

IDC MarketScape vendor analysis model is designed to provide an overview of the competitive fitness of suppliers in a given market. The research methodology utilizes a rigorous scoring methodology based on both qualitative and quantitative criteria that results in a single graphical illustration of each vendor's position within a given market. IDC MarketScape provides a clear framework in which the product and service offerings, capabilities and strategies, and current and future market success factors of vendors can be meaningfully compared. The framework also provides buyers with a 360-degree assessment of the strengths and weaknesses of current and prospective vendors.

About PwC's Advisory Practice

PwC's Advisory professionals help organizations improve business performance, respond quickly and effectively to crisis, and extract value from transactions. We understand our clients' industries and unique business challenges, and look across the entire organization -- focusing on strategy, structure, people, process and technology -- to help clients build their next competitive advantage. See http://www.pwc.com/us/consulting for more information.

About the PwC Network

PwC firms help organizations and individuals create the value they're looking for. We're a network of firms in 158 countries with close to 169,000 people who are committed to delivering quality in assurance, tax and advisory services. Tell us what matters to you and find out more by visiting us at www.pwc.com .? 2012 PricewaterhouseCoopers LLP, a Delaware limited liability partnership. All rights reserved. PwC refers to the US member firm, and may sometimes refer to the PwC network. Each member firm is a separate legal entity. Please see www.pwc.com/structure for further details.

Source: http://consultancynews.blogspot.com/2012/03/pwc-named-leader-in-global-business.html

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Internet Marketing Strategies For Your Online Business | Best Home ...

[unable to retrieve full-text content]There are several factors responsible for the tremendous upsurge seen with internet marketing, and the this trend has no apparent end in sight. In this articles we'll cover just a few good online marketing tips you can put to ...

Source: http://www.besthomebusinessresources.com/internet-marketing-strategies-for-your-online-business/

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Friday, March 30, 2012

Promote your Website Online | Blog - Softtrix Web Solutions

The trend of doing business online is increasing with every single day, and maximizing the profitability of the business through the website is at the highest priority of the owners. If you have an excellent website but don?t have enough traffic for your websites then the sales revenue of your company will be lower. There are various methods of promoting your website for higher traffic like getting back links from article or directory submission and many other advertising programs. But not all of us have enough time to do all these tasks on our own. So there is another easy option for the web owners to divert more traffic to their websites, and it is hire a professional who can do this for you.

Promote websites Online

Softrix is one of the most competent web based companies that can provide every kind of web solution from web designing to its promotion. Whether you are a new business looking for an eye catching website or an existing business looking for more potential clients to your website, Softrix can provide you satisfactory results. You might find many other companies claiming they will provide bulk traffic to your websites but do you know that all the traffic which they divert to your websites is not your potential clients? Yes, that?s true and many website owners spend their money for nothing at the end. Softrix guarantees the quality traffic to your websites in order to increase your sales revenue. That?s why customers make Softrix as their lifetime web solution once they enjoy the marvelous services.

One of the leading search engines is Google today, and recently Softrix has been recognized by them as the Google Adword certified partners. So this means that the company is performing above standards and being a website owner you can trust their services to boost up your business. The professional team of Softrix provides the best internet marketing services from email marketing to search engine optimization (SEO).

In order to increase the traffic towards any website, higher ranking of that website in the search engines is really important. It is only possible with smart and professional thinking to create content and keywords that are search engine friendly to place your website at first pages of the search engine. The professional search engine optimization team of Softrix can handle it all for you. So you can trust the guaranteed SEO services, Web Design Service, PPC service of Softrix to promote your website for higher profits.

Source: http://www.softtrix.com/blog/search-engine-optimization/promote-your-website-online/

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War On Words: NYC Dept. Of Education Wants 50 'Forbidden' Words ...

[unable to retrieve full-text content]War On Words: NYC Dept. Of Education Wants 50 'Forbidden' Words Banned From Standardized Tests March 29, 2012 Print Version Fearing that.

Source: http://waronyou.com/topics/war-on-words-nyc-dept-of-education-wants-50-forbidden-words-banned-from-standardized-tests/

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Millennial Media Shares Pop 100 Percent In Early Trading; Valued At Nearly $2 Billion

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Mobile ad network Millennial Media just debuted on the New York Stock Exchange under the symbol ?MM,? and saw shares pop 97 percent in the first trade of $25. The company initially priced its IPO at $13 per share last night, after increasing the range on Tuesday. At $25 per share, Millennial's valuation jumps to nearly $2 billion. Trading reached as high as $27.90 in early trading. Millennial which filed its original S-1 in early January, raised over $130 million in the offering, which is up from $75 million originally stated in earlier filings.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/QNJSduAAjdc/

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| Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/210376144?client_source=feed&format=rss

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Reading "White Coat, Black Hat" and discovering that ethicists might be black hats.

During one of my trips this spring, I had the opportunity to read Carl Elliott?s book White Coat, Black Hat: Adventures on the Dark Side of Medicine. It is not always the case that reading I do for my job also works as riveting reading for air travel, but this book holds its own against any of the appealing options at the airport bookstore. (I actually pounded through the entire thing before cracking open the other book I had with me, The Girl Who Kicked the Hornet?s Nest, in case you were wondering.)

Elliott takes up a number of topics of importance in our current understanding of biomedical research and how to do it ethically. He considers the role of human subjects for hire, of ghostwriters in the production of medical papers, of physicians who act as consultants and spokespeople for pharmaceutical companies, and of salespeople for the pharmaceutical companies who interact with scientists and physicians. There are lots of important issues here, engagingly presented and followed to some provocative conclusions. But the chapter of the book that gave me the most to think about, perhaps not surprisingly, is the chapter called ?The Ethicists?.

You might think, since Elliott is writing a book that points out lots of ways that biomedical research could be more ethical, that he would present a picture where ethicists rush in and solve the problems created by unwitting research scientists, well-meaning physicians, and profit driven pharmaceutical company. However, Elliott presents instead reasons to worry that professional ethicists will contribute to the ethical tangles of the biomedical world rather than sorting them out. Indeed Elliott identifies what seem to be special vulnerabilities in the psyche of the professional ethicist. For example, he writes, ?There is no better way to enlist bioethicists in the cause of consumer capitalism than to convince them they are working for social justice.? (139-140) Who, after all, could be against social justice? Yet, when efforts on behalf of social justice takes the form of debates on television news programs about fair access to new pharmaceuticals, the big result seems to be free advertising for the companies making those pharmaceuticals. Should bioethicists be accountable for these unforeseen results? This chapter suggests that careful bioethicists ought to foresee them, and to take responsibility.

There is an irony in professionals who see part of their job as pointing out conflicts of interest to others that they may be placing themselves right in the path of equally overwhelming conflicts of interest. Some of these have to do with the practical problem of how to fund their professional work. Universities these days are struggling with reduced budgets, which means they are encouraging their faculty to be more entrepreneurial ? including by cultivating relationships that might lead to donations from the private sector. To the extent that bioethics is seen as relevant to pharmaceutical development, pharmaceutical companies, which have deeper pockets than do universities, are seen as attractive targets for fundraising.

As Elliott notes, bioethicists have seen a great deal of success in this endeavor. He writes,

For the last three decades bioethics has been vigorously generating new centers, new commissions, new journals, and new graduate programs, not to mention a highly politicized role in American public life. In the same way that sociologists saw their fortunes climb during the 1960s as the public eye turned towards social issues like poverty, crime, and education, bioethics started to ascend when medical care and scientific research began generating social questions of their own. As the field grows more prominent, bioethicists are considering a funding model familiar to the realm of business ethics, one that embraces partnership and collaboration with corporate sponsors as long as outright conflict of interest can be managed. ?

Corporate funding present a public relations challenge, of course. It looks unseemly for an ethicist to share in the profits of arms dealers, industrial polluters, or multinationals that exploit the developing world. Credibility is also a concern. Bioethicist teach about pharmaceutical company issues in university classrooms, write about those issues in books and articles, and comment on them in the press. Many bioethicists evaluate industry policies and practices for professional boards, government bodies, and research ethics committees. To critics, this raises legitimate questions about the field of bioethics itself. Where does the authority of ethicists come from, and why are corporations so willing to fund them? (140-141)

That comparison of bioethics to business, by the way, is the kind of thing that gets my attention; one of the spaces frequently assigned for ?Business and Professional Ethics? courses at my university is the Arthur Anderson Conference Room. Perhaps this is a permanent teachable moment, but I can?t help worry that really the lesson has to do with the vulnerability of the idealistic academic partner in the academic-corporate partnership.

Where does the authority of ethicist come from? I have scrawled in the margin something about appropriate academic credentials and good arguments. But connect this first question to Elliott?s second question: why are corporations so willing to fund them? Here, we need to consider the possibility that their credibility and professional status is, in a pragmatic sense, directly linked to corporations paying bioethicists for their labors. What, exactly, are those corporations paying for?

Let?s put that last question aside for a moment.

Arguably, the ethicist has some skills and training that render her a potentially useful partner for people trying to work out how to be ethical in the world. One hopes what she says would be informed by some amount of ethical education, serious scholarship, and decision-making strategies grounded in a real academic discipline.

Elliott notes that ?[s]ome scholars have recoiled, emphatically rejecting the notion that their voices should count more than others? on ethical affairs.? (142) Here, I agree if the claim is, in essence, that the interests of the bioethicists are no more important than others?. Surely the perspectives of others who are not ethicists matter, but one might reasonably expect that ethicists can add value, drawing on their experience in taking those interests, and the interest of other stakeholders, into account to make reasonable ethical decisions.

Maybe, though, those of us who do ethics for a living just tell ourselves we are engaged in a more or less objective decision-making process. Maybe the job we are doing is less like accounting and more like interpreting pictures in inkblots. As Elliott writes,

But ethical analysis does not really resemble a financial audit. If a company is cooking its books and the accountant closes his eyes to this fact in his audit, the accountant?s wrongdoing can be reliably detected and verified by outside monitors. It is not so easy with an ethics consultant. Ethicists have widely divergent views. They come from different religious standpoints, use different theoretical frameworks, and profess different political philosophies. Also free to change their minds at any point. How do you tell the difference between an office consultant who has changed her mind for legitimate reasons and one who has changed her mind for money? (144)

This impression of the fundamental squishiness of the ethicist?s stock in trade seems to be reinforced in a quote Elliott takes from biologist-entrepreneur Michael West: ?In the field of ethics, there are no ground rules, so it?s just one ethicist opinion versus another ethicist?s opinion. You?re not getting whether someone is right or wrong, because it all depends on who you pick.? (144-145)

Here, it will probably not surprise you to learn that I think these claims are only true when the ethicists are doing it wrong.

What, then, would be involved in doing it right? To start with, what one should ask from an ethicist should be more than just an opinion. One should also ask for an argument to support that opinion, an argument that makes reference to important details like interested parties, potential consequences of the various options for action on the table, the obligations the party making the decisions to the stakeholders, and so forth ? not to mention consideration of possible objections to this argument. It is fair, moreover, to ask the ethicist whether the recommended plan of action it is compatible with more than one ethical theory ? or, for example, if it only works in the world we are sharing solely with other Kantians.

This would not make auditing the ethical books as easy as auditing the financial statements, but I think it would demonstrate something like rigor and lend itself to meaningful inspection by others. Along the same lines, I think it would be completely reasonable, in the case that an ethicist has gone on record as changing her mind, to ask for the argument that brought her from one position to the other. It would also be fair to ask, what argument or evidence might bring you back again?

Of course, all of this assumes an ethicist arguing in good faith. It?s not clear that what I?ve described as crucial features of sound ethical reasoning couldn?t be mimicked by someone who wanted to appear to be a good ethicist without going to the trouble of actually being one.

And if there?s someone offering you money ? maybe a lot of money ? for something that looks like good ethical reasoning, is there a chance you could turn from an ethicist arguing in good faith to one who just looks like she is, perhaps without even being aware of it herself?

Elliott pushes us to examine whether the dangers that may lurk when the private-sector interests are willing to put up money for your ethical insight. Have they made a point of asking for your take primarily because your paper-trail of prior ethical argumentation lines us really well with what they would like an ethicist to say to give them cover to do what they already want to do ? not because it?s ethical, necessarily, but because it?s profitable or otherwise convenient? You may think your ethical stances are stable because they are well-reasoned (or maybe even right). But how can you be sure that the stability of your stance is not influenced by the size of your consultation paycheck? How can you tell that you have actually been solicited for an honest ethical assessment ? one that, potentially, could be at odds with what the corporation soliciting it wants to hear? If you tell that corporation that a certain course of action would be unethical, do you have any power to prevent them from pursuing that course of action? Do you have an incentive to tell the corporation what it wants to hear, not just to pick up your consulting fee, but to keep a seat at the table where you might hope to have a chance of nudging its behavior in a more ethical direction, even if only incrementally?

None of these are easy questions to answer objectively if you?re the ethicist in the scenario.

Indeed, even if money were not part of the equation, the very fact that people at the corporations ? or researchers, or physicians, or whoever it is seeking the ethicists? expertise ? are reaching out to ethicists and identifying them as experts with something worthwhile to contribute might itself make it harder for the ethicists to deliver what they think they should. As Elliott argues, the personal relationships may end up creating conflicts of interest that are at least as hard to manage as those that occur when money changes hands. These people asking for our ethical input seem like good folks, motivated at least in part by goals (like helping people with disease) that are noble. We want them to succeed. And we kind of dig that they seem interested in what we have to say. Because we end up liking them as people, we may find it hard to tell them things they don?t want to hear.

And ultimately, Elliott is arguing, barriers to delivering news that people don?t want to hear ? whether those barriers come from financial dependence, the professional prestige that comes when your talents are in demand, or developing personal relationships with the people you?re advising ? are barriers to being a credible ethicist. Bioethics becomes ?the public relations division of modern medicine? (151) rather than carrying on the tradition of gadflies like Socrates. If they were being Socratic gadflies and telling truth to power, Elliott suggests, we would surely be able to find at least a few examples of bioethics who were punished for their candor. Instead, we see the ties between ethicists and the entities they advise growing closer.

This strikes close to home for me, as I aspire to do work in ethics that can have real impacts on the practice of scientific knowledge-building, the training of new scientists, the interaction of scientists with the rest of the world. On the one hand, it seems to help me to understand the details of scientific activity, and the concerns of scientists and scientific trainees. But, if I ?go native? in the tribe of science, Elliott seems to be saying that I could end up dropping the ball as far as what it means to make the kind of contribution a proper ethicist should:

Bioethicists have gained recognition largely by carving out roles as trusted advisers. But embracing the role of trusted adviser means forgoing other potential roles, such as that of the critic. It means giving up on pressuring institutions from the outside, in the manner of investigative reporters. As bioethicists seek to become trusted advisers, rather than gadflies or watchdogs, it will not be surprising if they slowly come to resemble the people they are trusted to advise. And when that happens, moral compromise will be unnecessary, because there will be little left to compromise. (170)

This is strong stuff ? the kind of stuff which, if taken seriously, I hope can keep me on track to offer honest advice even when it?s not what the people or institutions to whom I?m offering it want to hear. Heeding the warnings of a gadfly like Carl Elliott might just help an ethicist do what she has to do to be able to trust herself.

Source: http://rss.sciam.com/click.phdo?i=3b2870467de962f79ac495229f914859

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Up to the Second Business Sales and Takeovers ? SOD Article ...

One of the biggest problem that those looking to sell or kopen bedrijven have always faced in no uncertain terms is that of timing. When it comes to putting up bedrijven te koop or looking for enterprises to take over, it pretty much goes without saying that being in the right place at the right time can be more important than all the business knowhow and savvy in the world today. The reason for this is of course the fact that each and every time a golden opportunity for a sale or a purchase comes about, chances are it will be gone within seconds and may never be repeated. It is for exactly such reasons why conventional publications offering business and company sales have been rather on the flawed side to say the very least, given the way in which it has been all-too possible to find all of the decent opportunities have already gone by the time the publication is fully distributed.

Thankfully however there is now an alternative, which comes in the form of the innovative online business sale and takeover resource. What sets the new alternative apart from the conventional is the way in which the sites operate in real time and are accessible for all parties 24 hours a day and 7 days a week, which means that buying and selling opportunities never need to be missed out on for any given reason. The result is the potential for more lucrative sales and buyouts than ever before, all for very little in return by way of payment.

Overnamematch is author of this article on kopen bedrijven. Find more information about bedrijven te koop.

Source: http://submitondirectory.com/article/2012/03/30/up-to-the-second-business-sales-and-takeovers/

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Total Recall: Sequels to Remakes

Total Recall: Sequels to Remakes - Rotten Tomatoes

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With Wrath of the Titans hitting theaters, we take a look at movies whose do-overs were popular enough to warrant a follow-up.

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Source: http://www.rottentomatoes.com/m/1924823/news/1924823/

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Irish Eyes Not Smiling Yet; No E-3 Visas | legal immigration ...

By Joe Guzzardi, CAPS Senior Writing Fellow. Guzzardi's Op-eds about California social issues have appeared in newspapers throughout California and elsewhere for 15 years., March 28, 2012 (16 hours ago)

Now that St. Patrick?s Day has passed, the chances for Massachusetts Senator Scott Brown?s legislation to issue to 10,500 E-3 visas to Irish nationals may be over too. Brown had identified St. Patrick?s Day as the date by which he had hoped to maneuver S. 2005, the Irish Recognition and Encouragement Act or IRE, through the Senate. Instead, as of March 27, nearly two weeks after the parades have ended and the shamrocks wilted, S. 2005 has only 3 cosponsors.

The bill?s failure has mystified the media. In the days leading up to St. Paddy?s, journalists wrote glowingly about S. 2005 and pointed out that, if passed, it would reverse years of discrimination against the Irish inadvertently created when Brown?s predecessor, Teddy Kennedy, championed the Immigration and Nationality Act of 1965.

Said Brown?s spokesman John Donnelly:

?For decades, the Irish have been unfairly shut out by our immigration laws while immigration from many other countries has sharply increased.? [Immigration Bill Draws Ire from Advocates, by Erin Kelly, USA Today, March 22, 2012]

Brown?s bill duplicates a 2005 program that allowed 10,500 Australians to come to the United States on E-3 visas. The E-3?s fine print may also include immigration status relief through waivers for some illegal alien Irish currently living and (possibly) working in the United States. In other words, for those Irish already in America, they would likely receive an amnesty.

Reporters incorrectly assumed that since the Irish are white and speak English, then Brown?s bill should be acceptable to Congress and Americans who oppose more liberal immigration laws?two groups that are also mostly white and English speaking.

The media?s superficial analysis confirms its complete failure to understand the patriotic immigration reform?s message. More immigration, regardless of the country of origin, creates more population growth and brings with it the attendant social problems related to larger numbers of people.

And reporters totally missed the IRE?s biggest drawback. Although Brown has advertized his legislation as one that will bring exceptionally talented workers to the United States, the fact is that Irish nationals can qualify by having a high school diploma (or the equivalent). In the event he has neither, then two years of work experience can substitute. Of the nearly 20 million unemployed or underemployed Americans, tens of thousands are high school educated. To import 10,500 unskilled workers from Ireland or anywhere else is indefensible and inexcusable.

While Brown?s bill appears to have stalled, our side can never afford to take anything for granted. Brown is likely to continue to push for S. 2005 during his re-election campaign between now and November. See CAPS legislative alert here and contact your Senators.

Source: http://www.caps-blog.org/articles/2012/03/28/irish-eyes-not-smiling-yet-no-e-3-visas/

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